In 2022, the Monarch Initiative signed a five-year collaboration agreement with SNOMED International to develop maps from the clinical terminology SNOMED CT to Human Phenotype Ontology (HPO), a standardized vocabulary of phenotypic abnormalities encountered in human disease, and to HPO from SNOMED CT.

In June 2022, the Observational Health Data Sciences and Informatics (OHDSI) community and SNOMED International formalized their long-time relationship with a five-year collaborative agreement that will benefit both of their user communities.

The collaboration provides OHDSI and its user community with comprehensive ontologies on specific healthcare domains and content such as devices, social determinants of health, disease severity scores and modifiers of cancers, as well as better concept definitions and resolutions of composite concepts in large-scale observational research.